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Comorbid patients have significantly elevated plasma kynurenine/tryptophan ratios, positively correlated with both constipation severity and depression scores (Myint and Kim, 2014)

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proposed an indirect anticancer effect of venetoclax with the aid of dendritic cells (DCs) in vivo, depicted as the imgration and antigen presentation capacity of conventional type-1 DCs being potentiated by the activation of the cGAS/STING pathway and the subsequent classical type-1 interferon pathway when BCL2 is genetically or pharmacollogically inhibited, which eventually improves the immunosurveillance capacity of T cells and enhances ICI therapeutic efficacy